A multimodal electrochemical approach to measure the effect of zinc on vesicular content and exocytosis in a single cell model of ischemia

Abstract Zinc ion is essential for normal brain function that modulates synaptic activity and neuronal plasticity it associated with memory formation. considered to be a contributing factor the pathogenesis of ischemia, but association between zinc ischemia on vesicular exocytosis unclear. In this study, we used combination chemical analysis methods cell model ischemia/reperfusion investigate exocytotic release content, as well effect alteration exocytosis. Oxygen–glucose deprivation reperfusion (OGDR) was an in vitro line. Exocytotic storage catecholamine content were increased following OGDR, resulting higher fraction during However, eliminated these increases OGDR remained unchanged. Understanding consequences accumulation at early stage should aid development therapeutic strategies reduce ischemic injury. As released has been suggested related presynaptic plasticity, insights are gained towards deciphering impairment.